Vaccinia virus A35R inhibits MHC class II antigen presentation.

Abstract

The Vaccinia virus gene A35R (Copenhagen designation) is highly conserved in mammalian-tropic poxviruses and is an important virulence factor, but its function was unknown. We show herein that A35 does not affect viral infectivity, apoptosis induction, or replication; however, we found that A35 significantly inhibited MHC class II-restricted antigen… (More)
DOI: 10.1016/j.virol.2009.11.008

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