Vaccinia-related kinase 1 promotes hepatocellular carcinoma by controlling the levels of cell cycle regulators associated with G1/S transition

@inproceedings{Lee2015VacciniarelatedK1,
  title={Vaccinia-related kinase 1 promotes hepatocellular carcinoma by controlling the levels of cell cycle regulators associated with G1/S transition},
  author={Namgyu Lee and Jung-Hee Kwon and Young Bae Kim and Seong-Hoon Kim and Sung Jin Park and Weiguang Xu and Hoe-Yune Jung and Kyong-Tai Kim and Hee Jung Wang and Kwan Yong Choi},
  booktitle={Oncotarget},
  year={2015}
}
We identified the specific role of vaccinia-related kinase 1 (VRK1) in the progression of hepatocellular carcinoma (HCC) and evaluated its therapeutic and prognostic potential. VRK1 levels were significantly higher in HCC cell lines than a normal hepatic cell line, and were higher in HCC than non-tumor tissue. VRK1 knockdown inhibited the proliferation of SK-Hep1, SH-J1 and Hep3B cells; moreover, depletion of VRK1 suppressed HCC tumor growth in vivo. We also showed that VRK1 knockdown increased… CONTINUE READING

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