Vaccinia Virus E3 Protein Prevents the Antiviral Action of ISG15

Abstract

The ubiquitin-like modifier ISG15 is one of the most predominant proteins induced by type I interferons (IFN). In this study, murine embryo fibroblast (MEFs) and mice lacking the gene were used to demonstrate a novel role of ISG15 as a host defense molecule against vaccinia virus (VACV) infection. In MEFs, the growth of replication competent Western Reserve… (More)
DOI: 10.1371/journal.ppat.1000096

Topics

9 Figures and Tables

Cite this paper

@article{Guerra2008VacciniaVE, title={Vaccinia Virus E3 Protein Prevents the Antiviral Action of ISG15}, author={Susana Guerra and Ana Isabel C{\'a}ceres and K P Knobeloch and Ivan David Horak and Mariano Est{\'e}ban}, journal={PLoS Pathogens}, year={2008}, volume={4}, pages={378 - 387} }