Vaccines and Guillain-Barré Syndrome

@article{Haber2009VaccinesAG,
  title={Vaccines and Guillain-Barr{\'e} Syndrome},
  author={P. Haber and J. Sejvar and Y. Mikaeloff and F. Destefano},
  journal={Drug Safety},
  year={2009},
  volume={32},
  pages={309-323}
}
Guillain-Barré syndrome (GBS) is the leading cause of acute flaccid paralysis in developed countries and is characterized by various degrees of weakness, sensory abnormalities and autonomic dysfunction. Although the underlying aetiology and pathophysiology of GBS are not completely understood, it is broadly believed that immune stimulation plays a role in its pathogenesis. Thus, since vaccines have an effect on the immune system it is biologically plausible that immunizations may be associated… Expand
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TLDR
It is shown that an association between vaccine administration and GBS has never been proven for most of debated vaccines, although it cannot be definitively excluded and the benefits of vaccination are clearly demonstrated by the eradication or enormous decline in the incidence of many vaccine-preventable diseases. Expand
Transient immunosuppression: a bridge between infection and the atypical autoimmunity of Guillain–Barré syndrome?
TLDR
A comprehensive hypothesis is suggested for the pathogenesis of GBS that is based on the assumption that the condition is due to a transient (or occasionally chronic) immune deficiency, as in most cases GBS follows an infection with pathogens known to induce immunosuppression. Expand
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TLDR
In the population of over 3 million members, during an 11-year period, risk of GBS recurrence was low, with no cases of recurrent GBS after influenza vaccination and none within 6 weeks after any vaccine. Expand
Guillain-Barré Syndrome Following H1N1 Immunization in a Pediatric Patient
TLDR
An 11-year-old boy was admitted to the hospital after presenting with facial diplegia; abdominal, forehead, and thigh pain; and acute cervical pain and a probable relationship between the clinical manifestations of GBS and the vaccine against influenza A (H1N1) received by the patient was revealed. Expand
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TLDR
The risk of GBS is not considered a legitimate reason to limit the administration of currently available vaccines, as only a trivial association or no association with GBS has been demonstrated. Expand
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TLDR
No increased risk of GBS was detected for vaccination against hepatitis B, influenza, hepatitis A, varicella, rabies, polio(live), diphtheria, pertuss(acellular), tetanusis, measles, mumps, rubella, Japanese Encephalitis, and meningitis vaccines. Expand
Guillain-Barré syndrome and influenza vaccines: A meta-analysis.
TLDR
The results of the present meta-analysis point to a small but statistically significant association between influenza vaccines, particularly the pandemic ones, and GBS, which is consistent with current explanations upon possible mechanisms for this condition to appear. Expand
Chapter 101 – Guillain–Barré Syndrome
TLDR
The core features of Guillain–Barre syndrome are the acute onset of an ascending, predominantly motor polyradiculoneuropathy associated with areflexia and elevated cerebrospinal fluid protein and the overlap with cases of pandysautonomia. Expand
Síndrome de Guillain-Barré em associação temporal com a vacina influenza A
TLDR
A four-year-old boy presented right thigh pain and ascending muscular weakness 15 days after the second dose of influenza A (H1N1) 2009 vaccine, and the preliminary reports from the American Surveillance Program suggest a significant association between Guillain-Barre syndrome and influenza A H1n1 2009 vaccination. Expand
Acute polyradiculoneuritis: Guillain-Barré syndrome.
TLDR
Treatment with plasmapheresis and intravenous immunoglobulins (IVIG) has been proven in placebo-controlled studies in adults with severe disease to speed up recovery significantly and in children with GBS, although their spontaneous course is frequently less severe. Expand
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TLDR
The most frequently identified cause of GBS is Campylobacter jejuni infection, which has been identified in up to 41% of patients and is associated with more severe disease and prolonged disability. Expand
Susceptibility to Guillain–Barré syndrome is associated to polymorphisms of CD1 genes
TLDR
Findings indicate that susceptibility to develop GBS is associated with polymorphisms of CD1E and CD1A genes. Expand
Immunologic studies of rabies vaccination‐induced Guillain‐Barré syndrome
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It is concluded that patients with GBS constitute a heterogeneous population and that different target antigens may serve as a focus for this presumed autoimmune disease. Expand
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TLDR
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TLDR
If there is any causal relation between measles vaccination and Guillain-Barré syndrome, data from the vaccination of more than 70 million children were not sufficient to detect a rise in the number of observed GBS cases beyond the expected number. Expand
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TLDR
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TLDR
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TLDR
Contrary to previous studies, it is found no correlation between oral polio vaccine administration and Guillain-Barré syndrome in 2 successive years (1995 and 1996) during a nationwide campaign targeting children less than 5 years old. Expand
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