Vaccines and Guillain-Barré Syndrome

  title={Vaccines and Guillain-Barr{\'e} Syndrome},
  author={Penina Haber and James Sejvar and Yann Mikaeloff and Frank Destefano},
  journal={Drug Safety},
Guillain-Barré syndrome (GBS) is the leading cause of acute flaccid paralysis in developed countries and is characterized by various degrees of weakness, sensory abnormalities and autonomic dysfunction. Although the underlying aetiology and pathophysiology of GBS are not completely understood, it is broadly believed that immune stimulation plays a role in its pathogenesis. Thus, since vaccines have an effect on the immune system it is biologically plausible that immunizations may be associated… 

Transient immunosuppression: a bridge between infection and the atypical autoimmunity of Guillain–Barré syndrome?

A comprehensive hypothesis is suggested for the pathogenesis of GBS that is based on the assumption that the condition is due to a transient (or occasionally chronic) immune deficiency, as in most cases GBS follows an infection with pathogens known to induce immunosuppression.

Post-COVID-19 vaccine Guillain-Barré syndrome; first reported case from Qatar

Post COVID-19 vaccination Guillain-Barre syndrome: three cases

All patients were diagnosed with acute motor axonal neuropathy (AMAN) type of GBS, on nerve conduction studies, and responded well to treatment with intravenous immunoglobulin (IVIg).

Recurrent Guillain-Barre syndrome following vaccination.

In the population of over 3 million members, during an 11-year period, risk of GBS recurrence was low, with no cases of recurrent GBS after influenza vaccination and none within 6 weeks after any vaccine.

Guillain-Barré Syndrome Following H1N1 Immunization in a Pediatric Patient

An 11-year-old boy was admitted to the hospital after presenting with facial diplegia; abdominal, forehead, and thigh pain; and acute cervical pain and a probable relationship between the clinical manifestations of GBS and the vaccine against influenza A (H1N1) received by the patient was revealed.

Emerging Infection, Vaccination, and Guillain–Barré Syndrome: A Review

The risk of GBS is not considered a legitimate reason to limit the administration of currently available vaccines, as only a trivial association or no association with GBS has been demonstrated.

Vaccines and the risk of Guillain-Barré syndrome

No increased risk of GBS was detected for vaccination against hepatitis B, influenza, hepatitis A, varicella, rabies, polio(live), diphtheria, pertuss(acellular), tetanusis, measles, mumps, rubella, Japanese Encephalitis, and meningitis vaccines.

Síndrome de Guillain-Barré em associação temporal com a vacina influenza A

A four-year-old boy presented right thigh pain and ascending muscular weakness 15 days after the second dose of influenza A (H1N1) 2009 vaccine, and the preliminary reports from the American Surveillance Program suggest a significant association between Guillain-Barre syndrome and influenza A H1n1 2009 vaccination.



Clinical and epidemiologic features of Guillain-Barré syndrome.

The most frequently identified cause of GBS is Campylobacter jejuni infection, which has been identified in up to 41% of patients and is associated with more severe disease and prolonged disability.

Immunologic studies of rabies vaccination‐induced Guillain‐Barré syndrome

It is concluded that patients with GBS constitute a heterogeneous population and that different target antigens may serve as a focus for this presumed autoimmune disease.

The risk of Guillain-Barré syndrome after tetanus-toxoid-containing vaccines in adults and children in the United States.

If an association exists between tetanus-toxoid-containing vaccines and Guillain-Barré syndrome, it must be extremely rare and not of public health significance.

Guillain-Barre syndrome occurring after rabies vaccination.

A case of Guillain-Barre syndrome secondary to sheep brain anti-rabies vaccine in a young boy, who presented with lower limb weakness with total recovery after treatment is reported.

Guillain-Barré syndrome following immunisation withHaemophilus influenzae type b conjugate vaccine

It is speculated that an excessive anti-PRP IgM antibody response to the vaccine might be the cause of GBS.

Risk of relapse of Guillain-Barré syndrome or chronic inflammatory demyelinating polyradiculoneuropathy following immunisation

Audited the recurrence of neurological symptoms following immunisation in patients with Guillain-Barre syndrome and chronic inflammatory demyelinating polyradiculoneuropathy.

An epidemiologic and clinical evaluation of Guillain-Barré syndrome reported in association with the administration of swine influenza vaccines.

As a result of a court order, computerized summaries of approximately 1,300 cases reported as Guillain-Barré syndrome by state health departments to the Centers for Disease Control during the

An Epidemiologic, Clinical, and Therapeutic Study of Childhood Guillain-Barré Syndrome in Kuwait: Is It Related to the Oral Polio Vaccine?

Contrary to previous studies, it is found no correlation between oral polio vaccine administration and Guillain-Barré syndrome in 2 successive years (1995 and 1996) during a nationwide campaign targeting children less than 5 years old.