Vaccines against Lyme disease: What happened and what lessons can we learn?

@article{Poland2011VaccinesAL,
  title={Vaccines against Lyme disease: What happened and what lessons can we learn?},
  author={G. Poland},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={2011},
  volume={52 Suppl 3},
  pages={
          s253-8
        }
}
  • G. Poland
  • Published 2011
  • Medicine
  • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
This article reviews events that led to the withdrawal of the only vaccine to prevent Lyme disease licensed in the United States. The primary issues that led to the vaccine's withdrawal appear to be a combination of vaccine safety concerns, sparked by a molecular mimicry hypothesis that suggested that the vaccine antigen, outer surface protein A, serves as an autoantigen and hence was arthritogenic; concerns raised by anti-vaccine groups regarding vaccine safety; vaccine cost; a difficult… Expand
View on PubMed
academic.oup.com
89 Citations
Highly Influential Citations
6
Background Citations
24
Methods Citations
1
Results Citations
1

89 Citations

Citation Type

Citation Type

Why is There Still no Human Vaccine Against Lyme Borreliosis?
  • 3
  • PDF
Inner Workings: Lyme disease vaccines face familiar challenges, both societal and scientific
  • Leah Shaffer
  • History, Medicine
  • Proceedings of the National Academy of Sciences
  • 2019
  • 3
  • PDF
Vaccination against Lyme disease: past, present, and future
  • 58
A systematic review and meta-analysis for the adverse effects, immunogenicity and efficacy of Lyme disease vaccines: Guiding novel vaccine development
  • 5
Vaccines for tick-borne diseases and cost-effectiveness of vaccination: a public health challenge to reduce the diseases’ burden
  • 18
  • Highly Influenced
  • PDF
The clinician's guide to the anti-vaccinationists' galaxy.
  • 53
  • PDF
Accepted Manuscript Review the Clinician's Guide to the Anti-vaccinationists' Galaxy the Clinician's Guide to the Anti-vaccinationists' Galaxy Department of Medicine
  • PDF
Lyme borreliosis: reviewing potential vaccines, clinical aspects and health economics
  • 13
  • Highly Influenced
Vaccinomics, adversomics, and the immune response network theory: individualized vaccinology in the 21st century.
  • 82
Broadly Protective Multivalent OspA Vaccine against Lyme Borreliosis, Developed Based on Surface Shaping of the C-Terminal Fragment
  • 6
  • PDF
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 24 REFERENCES
The prevention of Lyme disease with vaccine.
  • 36
The Lyme vaccine: a cautionary tale
  • 79
  • PDF
Recommendations for the use of Lyme disease vaccine. Recommendations of the Advisory Committee on Immunization Practices (ACIP)
  • S. Hewitt
  • Medicine
  • MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports
  • 1999
  • 47
  • PDF
Vaccination against Lyme disease with recombinant Borrelia burgdorferi outer-surface lipoprotein A with adjuvant. Lyme Disease Vaccine Study Group.
  • 480
Vaccination against Lyme Disease with Recombinant Borrelia burgdorferi Outer-Surface Lipoprotein A with Adjuvant
  • 254
  • PDF
A vaccine consisting of recombinant Borrelia burgdorferi outer-surface protein A to prevent Lyme disease. Recombinant Outer-Surface Protein A Lyme Disease Vaccine Study Consortium.
  • 305
Evaluation of the safety, reactogenicity and immunogenicity of three recombinant outer surface protein (OspA) lyme vaccines in healthy adults.
  • 62
Arthritis following recombinant outer surface protein A vaccination for Lyme disease.
  • 31
  • Highly Influential
Adverse event reports following vaccination for Lyme disease: December 1998-July 2000.
  • 81
Autoimmune mechanisms in antibiotic treatment-resistant lyme arthritis.
  • 105
...
1
2
3
...