Vaccines against Lyme disease: What happened and what lessons can we learn?

@article{Poland2011VaccinesAL,
  title={Vaccines against Lyme disease: What happened and what lessons can we learn?},
  author={Gregory A. Poland},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={2011},
  volume={52 Suppl 3},
  pages={
          s253-8
        }
}
  • G. Poland
  • Published 1 February 2011
  • Biology
  • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
This article reviews events that led to the withdrawal of the only vaccine to prevent Lyme disease licensed in the United States. The primary issues that led to the vaccine's withdrawal appear to be a combination of vaccine safety concerns, sparked by a molecular mimicry hypothesis that suggested that the vaccine antigen, outer surface protein A, serves as an autoantigen and hence was arthritogenic; concerns raised by anti-vaccine groups regarding vaccine safety; vaccine cost; a difficult… 
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