Vaccines: the pentavalent rotavirus vaccine: discovery to licensure and beyond.

@article{Heaton2007VaccinesTP,
  title={Vaccines: the pentavalent rotavirus vaccine: discovery to licensure and beyond.},
  author={Penny M. Heaton and Max Ciarlet},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={2007},
  volume={45 12},
  pages={1618-24}
}
Twenty-five years passed between the discovery of the parent strain (WC3) of the pentavalent human-bovine reassortant rotavirus vaccine (PRV) in 1981 and the licensure of PRV in 2006. This orally administered liquid vaccine, which is given as a 3-dose series, is indicated for the prevention of rotavirus gastroenteritis, caused by the G serotypes contained in the vaccine, in infants and children. PRV is recommended by the Advisory Committee on Immunization Practices and the American Academy of… CONTINUE READING

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