Vaccines: correlates of vaccine-induced immunity.

@article{Plotkin2008VaccinesCO,
  title={Vaccines: correlates of vaccine-induced immunity.},
  author={Stanley A. Plotkin},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={2008},
  volume={47 3},
  pages={401-9}
}
The immune system is redundant, and B and T cells collaborate. However, almost all current vaccines work through induction of antibodies in serum or on mucosa that block infection or interfere with microbial invasion of the bloodstream. To protect, antibodies must be functional in the sense of neutralization or opsonophagocytosis. Correlates of protection after vaccination are sometimes absolute quantities but often are relative, such that most infections are prevented at a particular level of… CONTINUE READING
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