Vaccine potential of a herpes simplex virus type 1 mutant with an essential glycoprotein deleted.

@article{Farrell1994VaccinePO,
  title={Vaccine potential of a herpes simplex virus type 1 mutant with an essential glycoprotein deleted.},
  author={Helen E Farrell and Cornelia S. McLean and Chris Harley and Stacey Efstathiou and Suzanne Inglis and Anthony C. Minson},
  journal={Journal of virology},
  year={1994},
  volume={68 2},
  pages={927-32}
}
Several approaches to the production of vaccines to human herpesviruses have been proposed. Subunit vaccines, subunits delivered by live vectors, and rationally attenuated vaccines have all been shown to be efficacious in animal models but suffer from uncertainties as to the roles of individual genes involved in pathogenesis and the most relevant components of the immune response required for protection in humans and the target antigens involved. With these problems in mind, we examined the… CONTINUE READING

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