Vaccine-induced reduction of Helicobacter pylori colonization in mice is interleukin-12 dependent but gamma interferon and inducible nitric oxide synthase independent.

@article{Garhart2003VaccineinducedRO,
  title={Vaccine-induced reduction of Helicobacter pylori colonization in mice is interleukin-12 dependent but gamma interferon and inducible nitric oxide synthase independent.},
  author={Christine Garhart and Frederick P. Heinzel and Steven J. Czinn and John G. Nedrud},
  journal={Infection and immunity},
  year={2003},
  volume={71 2},
  pages={
          910-21
        }
}
Previous studies with mice have shown that major histocompatibility complex class II (MHC-II) is required for protection from Helicobacter pylori, while MHC-I and antibodies are not. Thus, CD4(+) T cells are presumed to play an essential role in protective immunity via secretion of cytokines. To determine which cytokines are associated with a reduction of bacterial load in immunized mice, gastric cytokine expression was examined by semiquantitative reverse transcription-PCR in protected… CONTINUE READING
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