Vaccine-induced early control of hepatitis C virus infection in chimpanzees fails to impact on hepatic PD-1 and chronicity.

@article{Rollier2007VaccineinducedEC,
  title={Vaccine-induced early control of hepatitis C virus infection in chimpanzees fails to impact on hepatic PD-1 and chronicity.},
  author={Christine S Rollier and Glaucia Paranhos-Baccala and Ernst J. Verschoor and Babs E. Verstrepen and Joost A. R. Drexhage and Zahra C. Fagrouch and Jean-Luc Berland and Florence Komurian-Pradel and Blandine Duverger and Nourredine Himoudi and Caroline Staib and Marcus Meyr and Mike Whelan and Joseph A. Whelan and Victoria C Adams and Esther Larrea and Jos{\'e} Ignacio Riezu and Juan J Lasarte and Birke Bartosch and Francois-L Cosset and Willy J. M. Spaan and Helmut Michael Diepolder and Gerd Rudolf Pape and Gerd Sutter and Genevi{\`e}ve Inchausp{\'e} and Jonathan Luke Heeney},
  journal={Hepatology},
  year={2007},
  volume={45 3},
  pages={602-13}
}
UNLABELLED Broad T cell and B cell responses to multiple HCV antigens are observed early in individuals who control or clear HCV infection. The prevailing hypothesis has been that similar immune responses induced by prophylactic immunization would reduce acute virus replication and protect exposed individuals from chronic infection. Here, we demonstrate that immunization of naïve chimpanzees with a multicomponent HCV vaccine induced robust HCV-specific immune responses, and that all vaccinees… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 44 extracted citations

Ever closer to a prophylactic vaccine for HCV

Expert opinion on biological therapy • 2013
View 7 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…