Vaccine-induced CD8+ T cells control AIDS virus replication

@article{Mudd2012VaccineinducedCT,
  title={Vaccine-induced CD8+ T cells control AIDS virus replication},
  author={Philip A. Mudd and Mauricio A Martins and Adam J Ericsen and Damien C. Tully and Karen A. Power and Alex Bean and Shari M. Piaskowski and Lijie Duan and Aaron M. Seese and Adrianne D. Gladden and Kim L. Weisgrau and Jessica R. Furlott and Young-il Kim and Marlon Gilsepp Veloso de Santana and Eva G Rakasz and Saverio Capuano and Nancy A. Wilson and Myrna C Bonaldo and Ricardo Galler and David B. Allison and Michael J. Piatak and Ashley T Haase and Jeffrey D Lifson and Todd M. Allen and David I. Watkins},
  journal={Nature},
  year={2012},
  volume={491},
  pages={129-133}
}
Developing a vaccine for human immunodeficiency virus (HIV) may be aided by a complete understanding of those rare cases in which some HIV-infected individuals control replication of the virus. Most of these elite controllers express the histocompatibility alleles HLA-B*57 or HLA-B*27 (ref. 3). These alleles remain by far the most robust associations with low concentrations of plasma virus, yet the mechanism of control in these individuals is not entirely clear. Here we vaccinate Indian rhesus… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 38 times over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 89 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 28 references

Understanding animalmodels of elite control : windows on effective immune responses against immunodeficiency viruses

  • J. T. Loffredo
  • Curr . Opin . HIV AIDS
  • 2011

windows on effective immune responses against immunodeficiency viruses

  • P. A. Mudd, Watkins, D. I. Understanding animal models of elite control
  • Curr. Opin. HIV AIDS 6, 197–201
  • 2011

clinical implicationsofunderstanding immunecontrol of HIV

  • S. A. Migueles, Connors, M. Long-term nonprogressive disease among untreated H individuals
  • J. Am. Med. Assoc. 304, 194–201
  • 2010

Effectormemory T cell responses are associatedwithprotection of rhesus monkeys frommucosal simian immunodeficiency virus challenge

  • S. G. Hansen
  • Nature Med .
  • 2009

Similar Papers

Loading similar papers…