Vaccine-induced CD8+ T cells control AIDS virus replication

  title={Vaccine-induced CD8+ T cells control AIDS virus replication},
  author={Philip A. Mudd and Mauricio A Martins and Adam J Ericsen and Damien C. Tully and Karen A. Power and Alex Bean and Shari M. Piaskowski and Lijie Duan and Aaron M. Seese and Adrianne D. Gladden and Kim L. Weisgrau and Jessica R. Furlott and Young-il Kim and Marlon Gilsepp Veloso de Santana and Eva G Rakasz and Saverio Capuano and Nancy A. Wilson and Myrna C Bonaldo and Ricardo Galler and David B. Allison and Michael J. Piatak and Ashley T Haase and Jeffrey D Lifson and Todd M. Allen and David I. Watkins},
Developing a vaccine for human immunodeficiency virus (HIV) may be aided by a complete understanding of those rare cases in which some HIV-infected individuals control replication of the virus. Most of these elite controllers express the histocompatibility alleles HLA-B*57 or HLA-B*27 (ref. 3). These alleles remain by far the most robust associations with low concentrations of plasma virus, yet the mechanism of control in these individuals is not entirely clear. Here we vaccinate Indian rhesus… CONTINUE READING
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