Vaccine for prevention of mild and moderate-to-severe influenza in children.

  title={Vaccine for prevention of mild and moderate-to-severe influenza in children.},
  author={Varsha K. Jain and Luis M. Rivera and Khalequz Zaman and Roberto A. Espos and Chukiat Sirivichayakul and Beatriz P. Quiambao and Doris Maribel Rivera-Medina and Pirunghul Kerdpanich and Mehmet Ali Ceyhan and Ener Cagri Dinleyici and Alejandro Cravioto and Mohammad Yunus and Pornthep Chanthavanich and Kriengsak Limkittikul and Zafer Kurugol and Emre Alhan and Adrian Caplanusi and Serge Durviaux and Philippe Boutet and Opokua Ofori-Anyinam and Vijayalakshmi Chandrasekaran and Ghassan S. Dbaibo and Bruce L. Innis},
  journal={The New England journal of medicine},
  volume={369 26},
BACKGROUND Commonly used trivalent vaccines contain one influenza B virus lineage and may be ineffective against viruses of the other B lineage. We evaluated the efficacy of a candidate inactivated quadrivalent influenza vaccine (QIV) containing both B lineages. METHODS In this multinational, phase 3, observer-blinded study, we randomly assigned children 3 to 8 years of age, in a 1:1 ratio, to receive the QIV or a hepatitis A vaccine (control). The primary end point was influenza A or B… CONTINUE READING


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