Vaccine escape in 2013–4 and the hydropathic evolution of glycoproteins of A/H3N2 viruses

@article{Phillips2016VaccineEI,
  title={Vaccine escape in 2013–4 and the hydropathic evolution of glycoproteins of A/H3N2 viruses},
  author={J. Phillips},
  journal={Physica A-statistical Mechanics and Its Applications},
  year={2016},
  volume={455},
  pages={38-43}
}
  • J. Phillips
  • Published 2016
  • Biology
  • Physica A-statistical Mechanics and Its Applications
More virulent strains of influenza virus subtypes H1N1 appeared widely in 2007 and H3N2 in 2011, and especially 2013–4, when the effectiveness of the H3N2 vaccine decreased by more than a factor of two. The amino acid differences of neuraminidase from prior less virulent strains appear to be small (<1%) when tabulated through sequence alignments and counting site identities and similarities. Here we show how analyzing fractal hydropathic forces responsible for neuraminidase globular compaction… Expand
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