Vaccine-elicited receptor-binding site antibodies neutralize two New World hemorrhagic fever arenaviruses

@inproceedings{Clark2018VaccineelicitedRS,
  title={Vaccine-elicited receptor-binding site antibodies neutralize two New World hemorrhagic fever arenaviruses},
  author={Lars E Clark and Selma Mahmutovi{\'c} and Donald Damian Raymond and Taleen Dilanyan and Takaaki Koma and John Tyler Manning and Sundaresh Shankar and Silvana C Levis and Ana M. Briggiler and Delia Alcira Enria and Kai W Wucherpfennig and Slobodan Paessler and Jonathan Abraham},
  booktitle={Nature Communications},
  year={2018}
}
While five arenaviruses cause human hemorrhagic fevers in the Western Hemisphere, only Junin virus (JUNV) has a vaccine. The GP1 subunit of their envelope glycoprotein binds transferrin receptor 1 (TfR1) using a surface that substantially varies in sequence among the viruses. As such, receptor-mimicking antibodies described to date are type-specific and lack the usual breadth associated with this mode of neutralization. Here we isolate, from the blood of a recipient of the live attenuated JUNV… CONTINUE READING
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SHOWING 1-10 OF 70 REFERENCES

Convergent immunological solutions to Argentine hemorrhagic fever virus neutralization.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2017

Structural basis for antibody-mediated neutralization of Lassa virus

Hastie, M K.
  • Science 356,
  • 2017

Structural basis for antibody-mediated neutralization of Lassa virus

Hastie, M K.
  • Science 356,
  • 2017

Crystal structure of the prefusion surface glycoprotein of the prototypic arenavirus LCMV

Hastie, M K.
  • Nat. Struct. Mol. Biol
  • 2016

Efficacy of convalescent plasma in relation to dose of ebola virus antibodies

J. van Griensven, T. Edwards, S. Baize, C. Ebola-Tx
  • N. Engl. J. Med
  • 2016

Evaluation of convalescent plasma for Ebola virus disease

J van Griensven
  • in Guinea. N. Engl. J. Med
  • 2016

Evaluation of convalescent plasma for Ebola virus disease in Guinea

J. van Griensven
  • N . Engl . J . Med .
  • 2016

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