Vaccine-elicited antibodies mediate antibody-dependent cellular cytotoxicity correlated with significantly reduced acute viremia in rhesus macaques challenged with SIVmac251.

@article{GmezRomn2005VaccineelicitedAM,
  title={Vaccine-elicited antibodies mediate antibody-dependent cellular cytotoxicity correlated with significantly reduced acute viremia in rhesus macaques challenged with SIVmac251.},
  author={V{\'i}ctor Ra{\'u}l G{\'o}mez-Rom{\'a}n and Linda J Patterson and David J Venzon and David J. Liewehr and Kris Aldrich and Ruth H. Florese and Marjorie Robert-Guroff},
  journal={Journal of immunology},
  year={2005},
  volume={174 4},
  pages={2185-9}
}
Effector cells armed with Abs can eliminate virus-infected target cells by Ab-dependent cellular cytotoxicity (ADCC), an immune mechanism that has been largely overlooked in HIV vaccine development. Here, we show that a prime/boost AIDS vaccine approach elicits potent ADCC activity correlating with protection against SIV in rhesus macaques (Macacca mulatta). Priming with replicating adenovirus type 5 host range mutant-SIV recombinants, followed by boosting with SIV gp120, elicited Abs with ADCC… CONTINUE READING
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