Vaccine efficacy of transcutaneous immunization with amyloid β using a dissolving microneedle array in a mouse model of Alzheimer's disease.

@article{Matsuo2014VaccineEO,
  title={Vaccine efficacy of transcutaneous immunization with amyloid β using a dissolving microneedle array in a mouse model of Alzheimer's disease.},
  author={Kazuhiko Matsuo and Hideaki Okamoto and Yasuaki Kawai and Ying-shu Quan and Fumio Kamiyama and Sachiko Hirobe and Naoki Okada and Shinsaku Nakagawa},
  journal={Journal of neuroimmunology},
  year={2014},
  volume={266 1-2},
  pages={1-11}
}
Vaccine therapy for Alzheimer's disease (AD) based on the amyloid cascade hypothesis has recently attracted attention for treating AD. Injectable immunization using amyloid β peptide (Aβ) comprising 1-42 amino-acid residues (Aβ1-42) as antigens showed therapeutic efficacy in mice; however, the clinical trial of this injected Aβ1-42 vaccine was stopped due… CONTINUE READING