Vaccine- and hepatitis B immune globulin-induced escape mutations of hepatitis B virus surface antigen.

@article{Cooreman2001VaccineAH,
  title={Vaccine- and hepatitis B immune globulin-induced escape mutations of hepatitis B virus surface antigen.},
  author={Michael P. Cooreman and Geert Leroux-Roels and Wilma Paulij},
  journal={Journal of biomedical science},
  year={2001},
  volume={8 3},
  pages={237-47}
}
Hepatitis B virus surface antigen (HBsAg) vaccination has been shown to be effective in preventing hepatitis B virus (HBV) infection. The protection is based on the induction of anti-HBs antibodies against a major cluster of antigenic epitopes of HBsAg, defined as the 'a' determinant region of small HBsAg. Prophylaxis of recurrent HBV infection in patients who have undergone liver transplantation for hepatitis B-related end-stage liver disease is achieved by the administration of hepatitis B… CONTINUE READING