Vaccine and Wild-Type Strains of Yellow Fever Virus Engage Distinct Entry Mechanisms and Differentially Stimulate Antiviral Immune Responses

@inproceedings{FernandezGarcia2016VaccineAW,
  title={Vaccine and Wild-Type Strains of Yellow Fever Virus Engage Distinct Entry Mechanisms and Differentially Stimulate Antiviral Immune Responses},
  author={Maria Dolores Fernandez-Garcia and Laurent Meertens and Maxime Chazal and Mohamed Lamine Hafirassou and Oph{\'e}lie Dejarnac and Alessia Zamborlini and Philippe Despr{\'e}s and Nathalie Sauvonnet and Fernando Arenzana-Seisdedos and Nolwenn Jouvenet and Ali Amara},
  booktitle={mBio},
  year={2016}
}
UNLABELLED The live attenuated yellow fever virus (YFV) vaccine 17D stands as a "gold standard" for a successful vaccine. 17D was developed empirically by passaging the wild-type Asibi strain in mouse and chicken embryo tissues. Despite its immense success, the molecular determinants for virulence attenuation and immunogenicity of the 17D vaccine are poorly understood. 17D evolved several mutations in its genome, most of which lie within the envelope (E) protein. Given the major role played by… CONTINUE READING
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