Vaccine against MUC1 antigen expressed in inflammatory bowel disease and cancer lessens colonic inflammation and prevents progression to colitis-associated colon cancer.

@article{Beatty2010VaccineAM,
  title={Vaccine against MUC1 antigen expressed in inflammatory bowel disease and cancer lessens colonic inflammation and prevents progression to colitis-associated colon cancer.},
  author={Pamela Lynn Beatty and Sowmya Sriram Narayanan and J. -F. Gari{\'e}py and Sarangarajan Ranganathan and Olivera Olja J Finn},
  journal={Cancer prevention research},
  year={2010},
  volume={3 4},
  pages={
          438-46
        }
}
Association of chronic inflammation with an increased risk of cancer is well established, but the contributions of innate versus adaptive immunity are not fully delineated. There has furthermore been little consideration of the role played by chronic inflammation-associated antigens, including cancer antigens, and the possibility of using them as vaccines to lower the cancer risk. We studied the human tumor antigen MUC1 which is abnormally expressed in colon cancers and also in inflammatory… CONTINUE READING

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