Vaccine adjuvants alum and MF59 induce rapid recruitment of neutrophils and monocytes that participate in antigen transport to draining lymph nodes.

@article{Calabro2011VaccineAA,
  title={Vaccine adjuvants alum and MF59 induce rapid recruitment of neutrophils and monocytes that participate in antigen transport to draining lymph nodes.},
  author={Samuele Calabro and Marco Tortoli and Barbara Christiane Baudner and A Pacitto and Mario Cortese and Derek T O'hagan and Ennio De Gregorio and Anja Seubert and Andreas Wack},
  journal={Vaccine},
  year={2011},
  volume={29 9},
  pages={
          1812-23
        }
}
Vaccine adjuvants such as alum and the oil-in-water emulsion MF59 are used to enhance immune responses towards pure soluble antigens, but their mechanism of action is still largely unclear. Since most adjuvanted vaccines are administered intramuscularly, we studied immune responses in the mouse muscle and found that both adjuvants were potent inducers of chemokine production and promoted rapid recruitment of CD11b(+) cells. The earliest and most abundantly recruited cell type are neutrophils… CONTINUE READING
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