Vaccine adjuvants: Current state and future trends

@article{Petrovsky2004VaccineAC,
  title={Vaccine adjuvants: Current state and future trends},
  author={Nikolai Petrovsky and Julio C Aguilar},
  journal={Immunology and Cell Biology},
  year={2004},
  volume={82}
}
The problem with pure recombinant or synthetic antigens used in modern day vaccines is that they are generally far less immunogenic than older style live or killed whole organism vaccines. This has created a major need for improved and more powerful adjuvants for use in these vaccines. With few exceptions, alum remains the sole adjuvant approved for human use in the majority of countries worldwide. Although alum is able to induce a good antibody (Th2) response, it has little capacity to… 

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