Vaccine adjuvants: Current state and future trends

  title={Vaccine adjuvants: Current state and future trends},
  author={Nikolai Petrovsky and Julio C Aguilar},
  journal={Immunology and Cell Biology},
The problem with pure recombinant or synthetic antigens used in modern day vaccines is that they are generally far less immunogenic than older style live or killed whole organism vaccines. This has created a major need for improved and more powerful adjuvants for use in these vaccines. With few exceptions, alum remains the sole adjuvant approved for human use in the majority of countries worldwide. Although alum is able to induce a good antibody (Th2) response, it has little capacity to… 

Improvements in Adjuvants for New-Generation Vaccines

There remains a need for improved adjuvants that enhance strong T-cell immunity and protective antibody response and a logical approach to the development of new and more effective vaccine adjuvant requires a better understanding of the action of adjuvant-antigen formulations.

Review on Recent Advance of Vaccine Adjuvants

Recent advances of vaccine adjuvants reveal their ability to activate innate immune system by targeting receptors (PRR) expressed on immune cells, which helps the development of more potent vaccine, which induce strong immune response.

Immune modulators with defined molecular targets: cornerstone to optimize rational vaccine design.

The development of new adjuvants which are able to promote broad and sustained immune responses at systemic and mucosal levels and which are currently under preclinical or clinical development will be described in this chapter.

Immune modulators with defined molecular targets: Cornerstone to optimize rational vaccine design

The development of new adjuvants which are able to promote broad and sustained immune responses at systemic and mucosal levels and are currently under preclinical or clinical development will be described in this chapter.

Carbohydrate-based immune adjuvants

The role for adjuvants in human vaccines has been a matter of vigorous scientific debate, with the field hindered by the fact that for over 80 years, aluminum salts were the only adjuvants approved

Polysaccharides: Candidates of promising vaccine adjuvants.

Polysaccharide-based compounds and formulations are potential vaccine adjuvant candidates because they can act as pathogen-associated molecular patterns and recognize pattern recognition receptors on immune cells, followed by triggering innate immunity and regulating adaptive immunity.

New Generation Vaccines : Need for Safe and Improved Adjuvants

To address life-threatening pandemic diseases and ever evolving drugresistant microbial infections worldwide, designing vaccines with safe and efficacious adjuvant is a major challenge for the scientific community that needs to be addressed systematically.

Introduce Characteristic, Types and Functional Mechanism of Adjuvants as a Biologic Complement

The present paper reviews the different types of adjuvants and examines the characteristics and mechanisms of their.

Trends in Adjuvant and Vaccine Delivery Systems

The gradual advances made in antigen discovery need to be complemented with new generation adjuvants for multidimensional effects and the foresight of the eminent threat warrants drastic revolution in this sector.

Comparative Safety of Vaccine Adjuvants: A Summary of Current Evidence and Future Needs

The biggest remaining challenge in the adjuvant field is to decipher the potential relationship between adjuvants and rare vaccine adverse reactions, such as narcolepsy, macrophagic myofasciitis or Alzheimer’s disease.



Inulin‐derived adjuvants efficiently promote both Th1 and Th2 immune responses

Inulin‐derived adjuvants that principally stimulate the innate immune system through their ability to activate the alternative complement pathway have proven ability to induce both cellular and humoral immunity, and offer great potential for use in a broad range of prophylactic and therapeutic vaccines.

Adjuvants and delivery systems for viral vaccines--mechanisms and potential.

The role of adjuvants in modern viral vaccine technology and their influence on the immune system are the subject of this review.

Future prospects for vaccine adjuvants.

The currently known agents capable of immunopotentiation and possible strategies for their use in future vaccines are discussed.

Adjuvants in perspective.

  • F. Vogel
  • Biology
    Developments in biological standardization
  • 1998
Novel adjuvant formulations can be designed that favour the development of Th1 (type 1) or Th2 (type 2) immune responses to vaccine antigens, including vaccines against HIV-1.

Synthetic immunomodulators and synthetic vaccines.

  • C. LeclercF. Vogel
  • Biology, Chemistry
    Critical reviews in therapeutic drug carrier systems
  • 1986
One MDP derivative presently under clinical trials has been shown to be adjuvant active but is devoid of pyrogenicity, and the mechanisms of activity of these MDP and derivative molecules will be discussed.

Immunological Adjuvants and Vaccines

This book contains the proceedings of the 1st NATO Advanced Studies Institute "Immunological Adjuvants and Vaccines" held in Cape Sounion Beach, Greece during 24 June-5 July, 1988.

Special Section:Future Trendsin Vaccination: Advances in cancer vaccine development

The optimal vaccine will elicit both humoral and cellular immunity in the patients as both parameters have been positively correlated with the induction of beneficial clinical responses and the choice of adjuvant, costimulation and delivery mode greatly determines the outcome of vaccinations.

Adjuvant influenza vaccines.

A trial in Britain has shown equally good adjuvant properties of the reversed emulsion incorporating influenza virus vaccine so far as serological response is concerned, although it has not yet been conducted on a scale that would allow of adequate evaluation of the likelihood of delayed local reactions.