Vaccine adjuvant systems containing monophosphoryl lipid A and QS21 induce strong and persistent humoral and T cell responses against hepatitis B surface antigen in healthy adult volunteers.

@article{Vandepapelire2008VaccineAS,
  title={Vaccine adjuvant systems containing monophosphoryl lipid A and QS21 induce strong and persistent humoral and T cell responses against hepatitis B surface antigen in healthy adult volunteers.},
  author={Pierre G Vandepapeli{\`e}re and Yves Horsmans and Philippe J. Moris and Marcelle Van Mechelen and Michel H. Janssens and Marguerite Christine Koutsoukos and Pascale Van Belle and Fr{\'e}d{\'e}ric Cl{\'e}ment and Emmanuel Hanon and Martine Anne Cecile Wettendorff and Nathalie Garçon and Geert Leroux-Roels},
  journal={Vaccine},
  year={2008},
  volume={26 10},
  pages={
          1375-86
        }
}
A randomised, double-blind study assessing the potential of four adjuvants in combination with recombinant hepatitis B surface antigen has been conducted to evaluate humoral and cell-mediated immune responses in healthy adults after three vaccine doses at months 0, 1 and 10. Three Adjuvant Systems (AS) contained 3-O-desacyl-4'-monophosphoryl lipid A (MPL) and QS21, formulated either with an oil-in-water emulsion (AS02B and AS02V) or with liposomes (AS01B). The fourth adjuvant was CpG… CONTINUE READING
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