Vaccine Pharmacotherapy for the Treatment of Cocaine Dependence

@article{Martell2005VaccinePF,
  title={Vaccine Pharmacotherapy for the Treatment of Cocaine Dependence},
  author={Bridget A. Martell and Ellen Siobhan Mitchell and James Poling and Kishorchandra Gonsai and Thomas R. Kosten},
  journal={Biological Psychiatry},
  year={2005},
  volume={58},
  pages={158-164}
}
Cocaine vaccine for the treatment of cocaine dependence in methadone-maintained patients: a randomized, double-blind, placebo-controlled efficacy trial.
TLDR
Attaining high (>or=43 microg/mL) IgG anticocaine antibody levels was associated with significantly reduced cocaine use, but only 38% of the vaccinated subjects attained these IgG levels and they had only 2 months of adequate cocaine blockade, so improved vaccines and boosters are needed.
Vaccines against stimulants: cocaine and MA
TLDR
A review of vaccine‐based approaches to treating stimulant addictions; specifically and cocaine addictions and new data related to pre‐clinical development of a methamphetamine (MA) vaccine are presented.
Immunotherapy for the treatment of drug abuse.
An antidote for acute cocaine toxicity.
TLDR
Contrary to the immunopharmacotherapeutic treatment of drug self-administration, minimal antibody doses were shown to counteract the lethality of a molar excess of circulating cocaine.
The &kgr;-opioid receptor gene as a predictor of response in a cocaine vaccine clinical trial
TLDR
This study indicates that a patient’s OPRK1 genotype could be used to identify a subset of individuals for whom vaccine treatment may be an effective pharmacotherapy for cocaine dependence.
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TLDR
The feasibility of a therapeutic cocaine vaccine for the treatment of cocaine addiction is established, with decreased levels of cocaine measured in the brain of immunized mice only 30 seconds after intravenous administration of cocaine.
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TLDR
It is suggested that immunopharmacotherapy may offer a promising means to treat cocaine abuse by aiding in the prevention of relapse and the ability of antibodies to block the reinforcing effects of the drug.
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TLDR
These findings underscore the significance of heterogeneity among cocaine abusers and the need to develop specialized treatments for clinically distinct subgroups of cocaine abusers.
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TLDR
It is reported here that active immunization with a new, stable cocaine conjugate suppressed locomotor activity and stereotyped behaviour in rats induced by cocaine but not by amphetamine, and suggest that immunopharmacotherapy may be a promising means by which to explore new treatments for cocaine abuse.
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TLDR
A delayed emergence of the effects of cognitive-behavioral relapse prevention is suggested, which may reflect the subjects' implementation of the generalizable coping skills conveyed through that treatment.
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TLDR
Voucher-based reinforcement contingencies can produce sustained cocaine abstinence in injecting polydrug abusers and the overall treatment quality significantly higher than controls.
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TLDR
There is no current evidence supporting the clinical use of CBZ, antidepressants, dopamine agonists, disulfiram, mazindol, phenytoin, nimodipine, lithium and NeuRecover-SA in the treatment of cocaine dependence.
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TLDR
Subjects who were treated with desipramine hydrochloride showed marked decreases in a measure of cocaine craving after two to three weeks of treatment and became abstinent regardless of whether an affective disorder was also present.
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