Vaccine-Induced T Cells Control Reversion of AIDS Virus Immune Escape Mutants

  title={Vaccine-Induced T Cells Control Reversion of AIDS Virus Immune Escape Mutants},
  author={C. Fernandez and M. Z. Smith and C. Batten and R. De Rose and J. Reece and E. Rollman and V. Venturi and M. Davenport and S. Kent},
  journal={Journal of Virology},
  pages={4137 - 4144}
ABSTRACT Many current-generation human immunodeficiency virus (HIV) vaccines induce specific T cells to control acute viremia, but their utility following infection with escape mutant virus is unclear. We studied reversion to wild type of an escape mutant simian-HIV in major histocompatibility complex-matched vaccinated pigtail macaques. High levels of vaccine-induced CD8+ T cells strongly correlated with maintenance of escape mutant virus during acute infection. Interestingly, in animals with… Expand
Quantification of simian immunodeficiency virus cytotoxic T lymphocyte escape mutant viruses.
  • L. Loh, S. Kent
  • Biology, Medicine
  • AIDS research and human retroviruses
  • 2008
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CD4+ Target Cell Availability Determines the Dynamics of Immune Escape and Reversion In Vivo
Complexity of the Inoculum Determines the Rate of Reversion of SIV Gag CD8 T Cell Mutant Virus and Outcome of Infection
Utility of Human Immunodeficiency Virus Type 1 Envelope as a T-Cell Immunogen


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High-Potency Human Immunodeficiency Virus Vaccination Leads to Delayed and Reduced CD8+ T-Cell Expansion but Improved Virus Control
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HIV evolution: CTL escape mutation and reversion after transmission