Vaccine Activation of the Nutrient Sensor GCN2 in Dendritic Cells Enhances Antigen Presentation

@article{Ravindran2014VaccineAO,
  title={Vaccine Activation of the Nutrient Sensor GCN2 in Dendritic Cells Enhances Antigen Presentation},
  author={Rajesh Ravindran and Nooruddin Khan and Helder I. Nakaya and Shuzhao Li and Jens Loebbermann and Mohan S Maddur and Youngja H Park and D. H. P. Jones and Pascal Chappert and Jean M. Davoust and David S Weiss and Herbert W Virgin and David Ron and Bali Pulendran},
  journal={Science},
  year={2014},
  volume={343},
  pages={313-317}
}
The yellow fever vaccine YF-17D is one of the most successful vaccines ever developed in humans. Despite its efficacy and widespread use in more than 600 million people, the mechanisms by which it stimulates protective immunity remain poorly understood. Recent studies using systems biology approaches in humans have revealed that YF-17D–induced early expression of general control nonderepressible 2 kinase (GCN2) in the blood strongly correlates with the magnitude of the later CD8+ T cell… CONTINUE READING