Vaccination with the ML0276 antigen reduces local inflammation but not bacterial burden during experimental Mycobacterium leprae infection.

@article{Raman2009VaccinationWT,
  title={Vaccination with the ML0276 antigen reduces local inflammation but not bacterial burden during experimental Mycobacterium leprae infection.},
  author={Vanitha S. Raman and Joanne A O'Donnell and Hilton R. Bailor and Wakako Goto and Ramanuj Lahiri and Thomas Gillis and Steven G Reed and Malcolm S. Duthie},
  journal={Infection and immunity},
  year={2009},
  volume={77 12},
  pages={5623-30}
}
Leprosy elimination has been a goal of the WHO for the past 15 years. Widespread BCG vaccination and multidrug therapy have dramatically reduced worldwide leprosy prevalence, but new case detection rates have remained relatively constant. These data suggest that additional control strategies, such as a subunit vaccine, are required to block transmission and to improve leprosy control. We recently identified several Mycobacterium leprae antigens that stimulate gamma interferon (IFN-gamma… CONTINUE READING