Vaccination with recombinant FimH fused with flagellin enhances cellular and humoral immunity against urinary tract infection in mice.

@article{Karam2013VaccinationWR,
  title={Vaccination with recombinant FimH fused with flagellin enhances cellular and humoral immunity against urinary tract infection in mice.},
  author={Mohammad Reza Asadi Karam and Mana Oloomi and Maziyar Mahdavi and M Kohi Habibi and Saeid Bouzari},
  journal={Vaccine},
  year={2013},
  volume={31 8},
  pages={1210-6}
}
Urinary tract infection (UTI) caused by Uropathogenic Escherichia coli (UPEC) is one of the most common infections in the world. Despite extensive efforts, a vaccine that confers protection against UTIs in human is currently lacking. In this study, the ability of flagellin (FliC), a Toll-like receptor 5 (TLR5) agonist of UPEC strain, and the conventional adjuvant Montanide ISA 206 to enhance the protective immune responses of FimH against urinary tract infection have been compared. Mice… CONTINUE READING

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