Vaccination with protein-transduced dendritic cells elicits a sustained response to hepatitis C viral antigens.

@article{Kuzushita2006VaccinationWP,
  title={Vaccination with protein-transduced dendritic cells elicits a sustained response to hepatitis C viral antigens.},
  author={Noriyoshi Kuzushita and Stephen H. Gregory and Nola A Monti and Rolf Carlson and Stephan Gehring and Jack R Wands},
  journal={Gastroenterology},
  year={2006},
  volume={130 2},
  pages={453-64}
}
BACKGROUND & AIMS Professional antigen-presenting dendritic cells are capable of eliciting a vigorous antiviral response in naive T cells. The administration of antigen-loaded dendritic cells offers a potential approach to induce high-level immunity against hepatitis C virus. METHODS The dendritic cell population in mice was expanded in vivo by hydrodynamic delivery of naked DNA that encoded the secreted form of human fms-like tyrosine kinase 3 ligand. The CD11c-enriched dendritic cell… CONTINUE READING
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