Vaccination with profilin encapsulated in oligomannose-coated liposomes induces significant protective immunity against Toxoplasma gondii.

@article{Tanaka2014VaccinationWP,
  title={Vaccination with profilin encapsulated in oligomannose-coated liposomes induces significant protective immunity against Toxoplasma gondii.},
  author={Sachi Tanaka and Yasuhiro Kuroda and Fumiaki Ihara and Maki Nishimura and Jun Hiasa and Naoya Kojima and Yoshifumi Nishikawa},
  journal={Vaccine},
  year={2014},
  volume={32 16},
  pages={
          1781-5
        }
}
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Plasmodium berghei circumsporozoite protein encapsulated in oligomannose-coated liposomes confers protection against sporozoite infection in mice
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Protective efficacy of oligomannose-coated liposome (OML)-entrapped merozoite and sporozoite antigens against Plasmodium berghei challenge infection in BALB/c mice was evaluated, and this approach may offer a new vaccination strategy against malaria infection.
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Immunization with Oligomannose-Coated Liposome-Entrapped Dense Granule Protein 7 Protects Dams and Offspring from Neospora caninum Infection in Mice
TLDR
Oligomannose-coated liposome-entrapped NcGRA7 can be used as a new type of effective vaccine to control neosporosis and increase offspring survival and decreased the infection rates in the brains of dams after parasite infection at 6 to 9 days of gestation.
Intraperitoneal immunization with oligomannose‐coated liposome‐entrapped soluble leishmanial antigen induces antigen‐specific T‐helper type immune response in BALB/c mice through uptake by peritoneal macrophages
TLDR
SLA‐OML were shown to successfully induce a specific Th1 immune response capable of controlling L. major infection in BALB/c mice through the effective uptake of OML by peritoneal macrophages.
Toxoplasma gondii Cyclophilin 18-Mediated Production of Nitric Oxide Induces Bradyzoite Conversion in a CCR5-Dependent Manner
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TLDR
A profilin-like molecule from the protozoan parasite Toxoplasma gondii is identified that generates a potent interleukin-12 (IL-12) response in murine DCs that is dependent on myeloid differentiation factor 88 and is the first chemically defined ligand for this TLR.
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