Vaccination with poly(IC:LC) and peptide-pulsed autologous dendritic cells in patients with pancreatic cancer

@inproceedings{Mehrotra2017VaccinationWP,
  title={Vaccination with poly(IC:LC) and peptide-pulsed autologous dendritic cells in patients with pancreatic cancer},
  author={Shikhar Mehrotra and Carolyn D. Britten and Steve H. Chin and Elizabeth L Garrett-Mayer and Colleen A. Cloud and Mingli Li and Gina M. Scurti and Mohamed Labib Salem and Michelle H Nelson and Melanie B. Thomas and Chrystal M. Paulos and Andres M. Salazar and Michael I. Nishimura and Mark P Rubinstein and Zihai Li and David J. Cole},
  booktitle={Journal of hematology & oncology},
  year={2017}
}
BACKGROUND Dendritic cells (DCs) enhance the quality of anti-tumor immune response in patients with cancer. Thus, we posit that DC-based immunotherapy, in conjunction with toll-like receptor (TLR)-3 agonist poly-ICLC, is a promising approach for harnessing immunity against metastatic or locally advanced unresectable pancreatic cancer (PC). METHODS We generated autologous DCs from the peripheral blood of HLA-A2+ patients with PC. DCs were pulsed with three distinct A2-restricted peptides: 1… CONTINUE READING
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