Vaccination with phosphoglycan-deficient Leishmania major protects highly susceptible mice from virulent challenge without inducing a strong Th1 response.

@article{Uzonna2004VaccinationWP,
  title={Vaccination with phosphoglycan-deficient Leishmania major protects highly susceptible mice from virulent challenge without inducing a strong Th1 response.},
  author={Jude Eze Uzonna and Gerald Frank Sp{\"a}th and Stephen M Beverley and Phillip Scott},
  journal={Journal of immunology},
  year={2004},
  volume={172 6},
  pages={3793-7}
}
Long-term immunity to Leishmania may require the continued presence of parasites, but previous attempts to create attenuated parasites that persist without causing disease have had limited success. Since Leishmania major mutants that lack lipophosphoglycan and other secreted phosphoglycans, termed lpg2-, persist indefinitely in infected mice without inducing any disease, we tested their ability to provide protection to virulent L. major challenge. In response to leishmanial Ag stimulation… CONTINUE READING

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