Vaccination with peptide 173-193 of acetylcholine receptor α7-subunit prevents memory loss in olfactory bulbectomized mice.

@article{Kamynina2010VaccinationWP,
  title={Vaccination with peptide 173-193 of acetylcholine receptor α7-subunit prevents memory loss in olfactory bulbectomized mice.},
  author={Anna V Kamynina and Olga M. Volpina and Natalya I Medvinskaya and Irina Ju Aleksandrova and Tatyana D. Volkova and Dmitriy O Koroev and Aleksandr N Samokhin and Inna V Nesterova and Irina V Shelukhina and Elena V. Kryukova and Viktor I Tsetlin and Vadim T. Ivanov and Natalya V Bobkova},
  journal={Journal of Alzheimer's disease : JAD},
  year={2010},
  volume={21 1},
  pages={249-61}
}
We studied the ability of four non-conjugated alpha7-subunit fragments of the nicotinic acetylcholine receptor to induce an immune response and to protect memory in olfactory bulbectomized mice which demonstrate abnormalities similar to Alzheimer's disease (AD). Vaccination only with the alpha7-subunit fragment 173-193 was shown to rescue spatial memory, to restore the level of alpha7 acetylcholine receptors in the cortex, and to prevent an increase in the amyloid-beta (Abeta) level in brain… CONTINUE READING
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New approaches to the immunotherapy of Alzheimer’s disease with the synthetic fragments of alpha7 subunit of the acetylcholine receptor

  • OM Volpina, TD Volkova, +9 authors NV Bobkova
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