Vaccination with coxsackievirus B3 virus-like particles elicits humoral immune response and protects mice against myocarditis.

@article{Zhang2012VaccinationWC,
  title={Vaccination with coxsackievirus B3 virus-like particles elicits humoral immune response and protects mice against myocarditis.},
  author={Li Zhang and Nick J Parham and Fangfang Zhang and Marl{\'e}n M. I. Aasa-Chapman and Ernest Andrew Gould and Houshuang Zhang},
  journal={Vaccine},
  year={2012},
  volume={30 13},
  pages={2301-8}
}
Coxsackievirus B3 (CVB3), along with other enteroviruses, is involved in about 50% of myocarditis cases and in the pathogenesis of dilated cardiomyopathy. Prevention of CVB3 infection is therefore highly desirable. Virus-like particles (VLPs) are structurally similar to native virus particles and therefore are far better immunogens than any other subunit vaccines. Recombinant baculoviruses carrying either the intact, entire coding region of CVB3 or the four individual coding regions for virus… CONTINUE READING

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