Vaccination with Toxoplasma gondii calcium-dependent protein kinase 6 and rhoptry protein 18 encapsulated in poly(lactide-co-glycolide) microspheres induces long-term protective immunity in mice.

@article{Zhang2016VaccinationWT,
  title={Vaccination with Toxoplasma gondii calcium-dependent protein kinase 6 and rhoptry protein 18 encapsulated in poly(lactide-co-glycolide) microspheres induces long-term protective immunity in mice.},
  author={Nianzhang Zhang and Ying Xu and Meng Wang and J Chen and Si-Yang Huang and Q. W. Gao and Xing-Quan Zhu},
  journal={BMC infectious diseases},
  year={2016},
  volume={16},
  pages={168}
}
BACKGROUND Toxoplasmosis is a worldwide zoonosis caused by the intracellular parasite Toxoplasma gondii. However, no effective vaccine is yet available. Poly(lactide-co-glycolide) polymers can reduce protein degradation and sustain the release of antigens over a long period, which could generate a long-lasting immune response in vivo. Using a mouse model of toxoplasmosis, we evaluated the protective efficacy of vaccination with two recombinant proteins, which are formulated in biodegradable… CONTINUE READING
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Toxoplasmosis of animals and humans

  • JP Dubey
  • 2nd ed. Boca Raton: CRC Press Inc;
  • 2010
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