Vaccination with Adjuvanted Recombinant Neuraminidase Induces Broad Heterologous, but Not Heterosubtypic, Cross-Protection against Influenza Virus Infection in Mice

@inproceedings{Wohlbold2015VaccinationWA,
  title={Vaccination with Adjuvanted Recombinant Neuraminidase Induces Broad Heterologous, but Not Heterosubtypic, Cross-Protection against Influenza Virus Infection in Mice},
  author={Teddy John Wohlbold and Raffael Nachbagauer and Haoming Xu and Gene S. Tan and Ariana Hirsh and Karl A Brokstad and Rebecca Jane Cox and P. Palese and Florian Krammer},
  booktitle={mBio},
  year={2015}
}
UNLABELLED In an attempt to assess the cross-protective potential of the influenza virus neuraminidase (NA) as a vaccine antigen, different subtypes of recombinant NA were expressed in a baculovirus system and used to vaccinate mice prior to lethal challenge with homologous, heterologous, or heterosubtypic viruses. Mice immunized with NA of subtype N2 were completely protected from morbidity and mortality in a homologous challenge and displayed significantly reduced viral lung titers… CONTINUE READING

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