Vaccination of vaccinia-naive adults with human immunodeficiency virus type 1 gp160 recombinant vaccinia virus in a blinded, controlled, randomized clinical trial. The AIDS Vaccine Clinical Trials Network.

@article{Graham1992VaccinationOV,
  title={Vaccination of vaccinia-naive adults with human immunodeficiency virus type 1 gp160 recombinant vaccinia virus in a blinded, controlled, randomized clinical trial. The AIDS Vaccine Clinical Trials Network.},
  author={B. Graham and R. Belshe and M. Clements and R. Dolin and L. Corey and P. Wright and G. Gorse and K. Midthun and M. Keefer and N. Roberts},
  journal={The Journal of infectious diseases},
  year={1992},
  volume={166 2},
  pages={
          244-52
        }
}
The safety and immunogenicity of a human immunodeficiency virus type 1 (HIV-1) gp160 recombinant vaccinia virus (HIVAC-1e) vaccine was evaluated in vaccinia-naive, healthy adults at low risk for acquiring HIV-1 infection. Volunteers (n = 36) were randomized to receive HIVAC-1e or control vaccinia virus at two dosages by bifurcated needle puncture at 0 and 2 months; 12 HIVAC-1e and 6 control vaccinia virus recipients received either 10(6) or 10(7) pfu/mL at each inoculation. There was no… Expand

Paper Mentions

Interventional Clinical Trial
Primary: To determine in healthy volunteers whether priming with a vaccinia HIV-1 gp160 envelope gene recombinant vaccine (HIVAC-1e) followed by boosting with one of two subunit… Expand
ConditionsHIV Infections
InterventionBiological
Human studies in the development of human immunodeficiency virus vaccines.
  • R. Dolin
  • Biology, Medicine
  • The Journal of infectious diseases
  • 1995
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