Vaccination of ponies with the IE gene of EHV-1 in a recombinant modified live vaccinia vector protects against clinical and virological disease.

@article{Soboll2010VaccinationOP,
  title={Vaccination of ponies with the IE gene of EHV-1 in a recombinant modified live vaccinia vector protects against clinical and virological disease.},
  author={Gisela Soboll and Cormac C. Breathnach and Julia H. Kydd and Stephen B. Hussey and R M Mealey and David P. Lunn},
  journal={Veterinary immunology and immunopathology},
  year={2010},
  volume={135 1-2},
  pages={
          108-17
        }
}
The control of EHV-1 infection by cytotoxic T-cell responses (CTL) via a reduction in cell associated viremia remains an important goal in horses. Unfortunately, current vaccines are inefficient at inducing these responses. We have identified the immediate early (IE) gene of EHV-1 as a potent stimulator of virus-specific CTL responses in ponies expressing a specific MHC class I serological haplotype (A3/B2). This study was designed to determine if vaccination of A3/B2 MHC I positive ponies with… CONTINUE READING
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