Vaccination of human subjects expands both specific and bystander memory T cells but antibody production remains vaccine specific.

@article{Genova2006VaccinationOH,
  title={Vaccination of human subjects expands both specific and bystander memory T cells but antibody production remains vaccine specific.},
  author={Gianfranco Di Genova and Joanna Roddick and Feargal McNicholl and Freda K Stevenson},
  journal={Blood},
  year={2006},
  volume={107 7},
  pages={2806-13}
}
Human subjects maintain long-term immunologic memory against infective organisms but the mechanism is unclear. CD4+ T-helper memory (Thmem) cells are pivotal in controlling humoral and cellular responses, therefore their longevity and response to vaccination are critical for maintenance of protective immunity. To probe the dynamics of the Thmem-cell response to antigenic challenge, we investigated subjects following a booster injection with tetanus toxoid (TT). Expansion of TT-specific Thmem… CONTINUE READING