Vaccination of dogs with six different candidate leishmaniasis vaccines composed of a chimerical recombinant protein containing ribosomal and histone protein epitopes in combination with different adjuvants.

@article{Poot2009VaccinationOD,
  title={Vaccination of dogs with six different candidate leishmaniasis vaccines composed of a chimerical recombinant protein containing ribosomal and histone protein epitopes in combination with different adjuvants.},
  author={Jacqueline Poot and Lambert H. M. Janssen and T J van Kasteren-Westerneng and Karin H A van der Heijden-Liefkens and Virgil E. J. C. Schijns and Anja R. Heckeroth},
  journal={Vaccine},
  year={2009},
  volume={27 33},
  pages={4439-46}
}
Chimerical protein "Q", composed of antigenic ribosomal and histone sequences, in combination with live BCG is a promising canine leishmaniasis vaccine candidate; one of the few vaccine candidates that have been tested successfully in dogs. Unfortunately, live BCG is not an appropriate adjuvant for commercial application due to safety problems in dogs. In order to find a safe adjuvant with similar efficacy to live BCG, muramyl dipeptide, aluminium hydroxide, Matrix C and killed… CONTINUE READING