Vaccination of cytotoxic T lymphocyte-directed peptides elicited and spread humoral and Th1-type immune responses to prostate-specific antigen protein in a prostate cancer patient.

@article{Harada2005VaccinationOC,
  title={Vaccination of cytotoxic T lymphocyte-directed peptides elicited and spread humoral and Th1-type immune responses to prostate-specific antigen protein in a prostate cancer patient.},
  author={Mamoru Harada and Satoko Matsueda and Akihisa Yao and Masanori Noguchi and Kyogo Itoh},
  journal={Journal of immunotherapy},
  year={2005},
  volume={28 4},
  pages={368-75}
}
The authors studied humoral and CD4+ T-cell responses in an HLA-A24+ prostate cancer patient vaccinated with cytotoxic T lymphocyte (CTL)-directed peptides, including a prostate-specific antigen (PSA)248-257 peptide, to understand what kinds of immune responses are elicited in peptide-vaccinated patients. The levels of immunoglobulin G (IgG) reactive to the administered PSA248-257 peptide or the PSA protein were kinetically examined. The level of IgG reactive to the PSA248-257 peptide… CONTINUE READING