Vaccination of chimpanzees against infection by the hepatitis C virus.

  title={Vaccination of chimpanzees against infection by the hepatitis C virus.},
  author={Q L Choo and G F Kuo and Robert Ralston and A. Weiner and David M Chien and Gary Van Nest and Jang Il Han and Kim Berger and Kent Thudium and C L Kuo},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={91 4},
A high incidence of community-acquired hepatitis C virus infection that can lead to the progressive development of chronic active hepatitis, liver cirrhosis, and primary hepatocellular carcinoma occurs throughout the world. A vaccine to control the spread of this agent that represents a major cause of chronic liver disease is therefore needed. Seven chimpanzees (Pan troglodytes) have been immunized with both putative envelope glycoproteins [E1 (gp33) and E2 (gp72)] that were copurified from… CONTINUE READING
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