Vaccination of Mice with Salmonella Expressing VapA: Mucosal and Systemic Th1 Responses Provide Protection against Rhodococcus equi Infection

Abstract

Conventional vaccines to prevent the pneumonia caused by Rhodococcus equi have not been successful. We have recently demonstrated that immunization with Salmonella enterica Typhimurium expressing the VapA antigen protects mice against R. equi infection. We now report that oral vaccination of mice with this recombinant strain results in high and persistent… (More)
DOI: 10.1371/journal.pone.0008644

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Cite this paper

@inproceedings{Oliveira2010VaccinationOM, title={Vaccination of Mice with Salmonella Expressing VapA: Mucosal and Systemic Th1 Responses Provide Protection against Rhodococcus equi Infection}, author={Aline Oliveira and Luciana Pereira Ruas and S{\'i}lvia Almeida Cardoso and Sandro Gomes Soares and Maria-Cristina Roque-Barreira}, booktitle={PloS one}, year={2010} }