Vaccination of Alzheimer's model mice with adenovirus vector containing quadrivalent foldable Abeta(1-15) reduces Abeta burden and behavioral impairment without Abeta-specific T cell response.

@article{Zou2008VaccinationOA,
  title={Vaccination of Alzheimer's model mice with adenovirus vector containing quadrivalent foldable Abeta(1-15) reduces Abeta burden and behavioral impairment without Abeta-specific T cell response.},
  author={Juntao Zou and Zhibin Yao and Ge Zhang and Hua-qiao Wang and Jie Xu and David Tai Wai Yew and Elizabeth Lucy Forster},
  journal={Journal of the neurological sciences},
  year={2008},
  volume={272 1-2},
  pages={87-98}
}
Active amyloid beta (Abeta) vaccination has been shown to be effective in clearing cerebral Abeta and improving cognitive function in mouse models of Alzheimer's disease (AD). The meningoencephalitis observed in AD vaccination trial was likely related to excessive T cell-mediated immunity caused by the immunogen Abeta(1-42). To avoid this toxicity, previous researchers have been using synthetic truncated Abeta derivatives that promote humoral immunity. In this study, we develop a novel… CONTINUE READING
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