Vaccination-induced circulation of human B cells secreting type-specific antibodies against pneumococcal polysaccharides.

@article{Heilmann1987VaccinationinducedCO,
  title={Vaccination-induced circulation of human B cells secreting type-specific antibodies against pneumococcal polysaccharides.},
  author={Carsten Heilmann and J\orgen Henrichsen and Freddy Karup Pedersen},
  journal={Scandinavian journal of immunology},
  year={1987},
  volume={25 1},
  pages={61-7}
}
Indirect plaque-forming cell assays detecting B cells secreting antibodies against capsular pneumococcal polysaccharide (PPS) antigens are described. In healthy adult volunteers the total number of B cells secreting IgM antibodies against the antigens in a polyvalent PPS vaccine reached a maximum in the blood 6 days after in vivo immunization (mean: 552/10(6) mononuclear cells), whereas the highest concentration of IgG and IgA antibody-secreting cells (SC) were detected 7 days after… CONTINUE READING