Vaccination and protection of pigs against pleuropneumonia with a vaccine strain of Actinobacillus pleuropneumoniae produced by site-specific mutagenesis of the ApxII operon.

@article{Prideaux1999VaccinationAP,
  title={Vaccination and protection of pigs against pleuropneumonia with a vaccine strain of Actinobacillus pleuropneumoniae produced by site-specific mutagenesis of the ApxII operon.},
  author={Christopher T. Prideaux and C. Lenghaus and J Krywult and Adrian L. M. Hodgson},
  journal={Infection and immunity},
  year={1999},
  volume={67 4},
  pages={
          1962-6
        }
}
  • Christopher T. Prideaux, C. Lenghaus, +1 author Adrian L. M. Hodgson
  • Published in Infection and immunity 1999
  • Medicine, Biology
  • The production of toxin (Apx)-neutralizing antibodies during infection plays a major role in the induction of protective immunity to Actinobacillus pleuropneumoniae reinfection. In the present study, the gene encoding the ApxII-activating protein, apxIIC, was insertionally inactivated on the chromosome of a serovar 7 strain, HS93. Expression of the structural toxin, ApxIIA, and of the two genes required for its secretion, apxIB and apxID, still occurs in this strain. The resulting mutant strain… CONTINUE READING

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