Vaccination against the HER-2/neu oncogenic protein.

  title={Vaccination against the HER-2/neu oncogenic protein.},
  author={H. Christian Bernhard and Lorena Salazar and Kathy A Schiffman and Arianna Smorlesi and Benjamin Schmidt and Keith L. Knutson and Mary Lenora Disis},
  journal={Endocrine-related cancer},
  volume={9 1},
The HER-2/neu oncogenic protein is a well-defined tumor antigen. HER-2/neu is a shared antigen among multiple tumor types. Patients with HER-2/neu protein-overexpressing breast, ovarian, non-small cell lung, colon, and prostate cancers have been shown to have a pre-existent immune response to HER-2/neu. No matter what the tumor type, endogenous immunity to HER-2/neu detected in cancer patients demonstrates two predominant characteristics. First, HER-2/neu-specific immune responses are found in… CONTINUE READING