Vaccination against high blood pressure: a new strategy

  title={Vaccination against high blood pressure: a new strategy},
  author={Ola Samuelsson and Hans Herlitz},
  journal={The Lancet},

Vaccine for hypertension: modulating the renin-angiotensin system.

Angiotensin vaccination: What is the prospect of success?

  • D. Campbell
  • Medicine, Biology
    Current hypertension reports
  • 2009
Angiotensin vaccination is being revisited as a strategy for treating hypertension, in the hope that new conjugates of angiotens in I and angiotENSin II will produce antibodies of sufficient titer and affinity to reduce blood pressure in patients with hypertension.

Vaccines in Development to Prevent and Treat Atherosclerotic Disease

A nicotine vaccine, an antiangiotensin vaccine, and an anti-obesity vaccine may play a therapeutic role in modifying known risk factors for the development of atherosclerosis and its complications.

Review: Update on Newer Antihypertensive Medicines and Interventions

A number of new pharmacologic targets and interventions as well as a novel method of drug delivery to patients are reviewed, which will help to facilitate attainment of optimal blood pressure levels.

Comparison of immunogenic efficacy of mono and polyvalent rabies vaccines in dogs

The monovalent vaccines were found to generate higher RVNA titers than the polyvalent vaccine, and gender of dogs did not affect vaccine efficacy except that gender had some effect on RVNA Titers generated by polyvalents vaccinated dogs.

Long-term humoral immunogenicity, safety and protective efficacy of inactivated vaccine against reindeer rabies

The data do not support the benefit of an adjuvanted vaccine for the prevention of rabies in reindeer and the efficient rabies vaccine injection dose is determined as equal to 3 ml.

Vaccines for Hypertension and Atherosclerosis

The development of vaccines for hypertension and atherosclerosis may be an important strategy for the prevention and treatment of these diseases.

[Renin-angiotensin-aldosterone system (RAAS) and its pharmacologic modulation].

The renin-angiotensin-aldosterone system is a neuroendocrine complex system that regulates the modulation of salt and water homeostasis, and regulation of blood pressure and regulates the vascular response to injury and inflammation.

Electrical carotid baroreceptor stimulation

In patients with resistant hypertension, electrically activation of the baroreflex leads to an average decrease in systolic blood pressure of 38, 36, 40 and 53 mmHg at 1, 2, 3 and 4 years, respectively.

Anästhesiologisches Management bei Implantation von Barorezeptorstimulatoren

Baroreceptor stimulators are novel implantable devices that activate the carotid baroreceptor reflex that results in a decrease in activity of the sympathetic nervous system and inhibition of the renin-angiotensin-aldosterone system in patients with drug-resistant hypertension.



A vaccine for hypertension

The successful production of angiotensin II antibodies in rats and humans, using a protein in which the N-terminus of the peptide is fused to a spacer sequence containing a cysteine, leading to conjugation with the surface of the highly repetitive structure of virus-like particles.

Randomized double-blind placebo-controlled study of an angiotensin immunotherapeutic vaccine (PMD3117) in hypertensive subjects.

Biochemical measurements show evidence of blockade of the renin system, but higher titres will be required to achieve a decrease in blood pressure, as shown in patients with essential hypertension.

Randomized double-blind placebo-controlled study of an angiotensin immunotherapeutic vaccine ( PMD 3117 ) in hypertensive subjects

Biochemical measurements show evidence of blockade of the renin system, but higher titres will be required to achieve a decrease in blood pressure.

Update on Elan vaccine for Alzheimer's disease

  • L. Spinney
  • Biology, Medicine
    The Lancet Neurology
  • 2004

Barriers to hypertension control.

Hyperkalemia with concomitant watery diarrhea: an unusual association.

Amyloid-β immunotherapy for Alzheimer's disease: the end of the beginning

  • D. Schenk
  • Biology, Psychology
    Nature Reviews Neuroscience
  • 2002
Immunotherapy represents one of the first tests of the amyloid hypothesis in the clinic, and is an evolving approach to the treatment of Alzheimer's disease that offers a genuine opportunity to modify disease progression.

Franz Volhard Lecture. Renin-angiotensin system: a dual tissue and hormonal system for cardiovascular control.

  • C. Johnston
  • Medicine, Biology
    Journal of hypertension. Supplement : official journal of the International Society of Hypertension
  • 1992
There is increasing evidence that the local renin-angiotensin system may be involved in the maintenance of cardiovascular structure and repair, and this provides a possible mechanism for the beneficial effect of ACE inhibitors in postmyocardial infarction trials.

Growth impairment in the very preterm and cognitive and motor performance at 7 years

Poor postnatal growth in preterm infants, especially of the head, is associated with increased levels of motor and cognitive impairment at 7 years of age, which appears to occur largely in the postnatal rather than antenatal period and may be amenable to intervention and subsequent improvement in outcome.