Vaccination against cutaneous leishmaniasis in a murine model. I. Induction of protective immunity with a soluble extract of promastigotes.

@article{Scott1987VaccinationAC,
  title={Vaccination against cutaneous leishmaniasis in a murine model. I. Induction of protective immunity with a soluble extract of promastigotes.},
  author={Phillip Scott and Edward Pearce and P C Natovitz and Alan Sher},
  journal={Journal of immunology},
  year={1987},
  volume={139 1},
  pages={221-7}
}
BALB/c mice can be protected against a fatal Leishmania major infection by immunization with whole radio-attenuated promastigotes; however, neither the antigens responsible for protection nor the protective immunologic mechanisms have been defined. In this study, the ability of promastigote fractions to elicit similar immunity to that obtained with whole organisms, and the immune responses associated with such protection were analyzed. Intraperitoneal immunization with a soluble, membrane-free… CONTINUE READING
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