Vaccination against autoimmune encephalomyelitis with T-lymphocite line cells reactive against myelin basic protein

@article{BenNun1981VaccinationAA,
  title={Vaccination against autoimmune encephalomyelitis with T-lymphocite line cells reactive against myelin basic protein},
  author={Avraham Ben-Nun and Hartmut Wekerle and Irun R. Cohen},
  journal={Nature},
  year={1981},
  volume={292},
  pages={60-61}
}
Despite differences in initiating events and pathophysiology, the aetiological agents of all autoimmune diseases are lymphocytes specifically reactive against normal constituents of the individual. Recently we have isolated and grown as a cell line rat T lymphocytes reactive against myelin basic protein (BP)1. This T-cell line originated from rats in which we had induced experimental autoimmune encephalomyelitis (EAE) by immunizing them against BP. Inoculation of syngeneic rats with the T-cell… CONTINUE READING