Vaccination against IL-17 suppresses autoimmune arthritis and encephalomyelitis.

@article{Rhn2006VaccinationAI,
  title={Vaccination against IL-17 suppresses autoimmune arthritis and encephalomyelitis.},
  author={Till Alexander R{\"o}hn and Gary T. Jennings and Marcela Hernandez and Paula Grest and Markus Beck and Yu Zou and Manfred Kopf and Martin F Bachmann},
  journal={European journal of immunology},
  year={2006},
  volume={36 11},
  pages={
          2857-67
        }
}
Interleukin 17 is a T cell-derived cytokine that induces the release of pro-inflammatory mediators in a wide range of cell types. Recently, a subset of IL-17-producing T helper cells (Th17) distinct from Th1 and Th2 cells has been described, which constitutes a new T cell polarization state. Aberrant Th17 responses and overexpression of IL-17 have been implicated in a number of autoimmune disorders including rheumatoid arthritis and multiple sclerosis. Molecules blocking IL-17 such as IL-17… CONTINUE READING
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